Geno Pharmaceuticals
 
 
 
Eleron Syrup
DAILY IRON INTAKE AND ABSORPTION

  DAILY IRON INTAKE AND ABSORPTION:

 

ABSORPTION OF IRON DEPENDS UPON THE FOLLOWING FACTORS:
(A) IRON REQUIREMENT OF THE SUBJECT-

The degree of immediate need of the body for iron determines the rate and amount of absorption from the small intestine. Iron absorption is increased during growth, menstruation, pregnancy and in blood disorders. Absorption is increased markedly when the iron needs are acute as in haemorrhage or in anaemias.

(B) FORM OF THE COMPOUND-
It is said that iron is best absorbed in ferrous (Fe + +) form. Most of the iron taken with food is in ferric (Fe + + +) form. They are at least partly converted into ferrous compounds before absorption. Organic iron of food is much less available for absorption than the inorganic. Insoluble forms are not absorbed.

(C) REACTION OF THE GASTRO-INTESTINAL CONTENTS-
The acidity of the gastric juice helps absorption. The gastric HCI helps in the liberation of iron from the organic compounds in diet. Reduction from ferric form to ferrous one takes place in stomach with the help of gastric secretions. Partial gastrectomy often leads to iron-deficiency anaemia.

(D) CALCIUM AND VITAMIN C-
A small amount of Ca decreases the formation of insoluble iron phosphates and thus helps absorption but large amounts of Ca inhibits iron assimilation. Vitamin C increases the absorption of iron from foods, possibly by reducing the ferric iron to the ferrous state.

Storage of Iron:
Iron is stored in two forms : ferritin and haemosiderin. The former is water-soluble while the latter is granular and insoluble in water. Reticulo-endothelial system in general particularly, liver, spleen and bone marrow store iron.

Absorption Regulation:
When the body has become saturated with iron so that essentially all of the appoferritin in the iron storage areas is already combined with iron, the rate of absorption of iron from the intestinal tract becomes greatly decreased.

AVERAGE RESPONSE TO ORAL IRON:

THERAPY WITH ORAL IRON:

Once a response to oral iron is demonstrated, therapy should be continued until the hemoglobin returns to normal. Treatment may be extended if it is desirable to establish iron stores. The prophylactic use of oral iron should be reserved for patients at high risk, including pregnant women, women with excessive menstrual blood loss and infants.

Orally administered ferrous sails are the usual choice in the treatment for iron deficiency. Ferrous salts are absorbed about three times as well as ferric salts, and the discrepancybecomes even greater at high dosage. Variations in the particular ferrous salt have relatively little effect on bioavailability, and the sulfate, fumarate, succinate, gluconate, and other ferrous salts are absorbed to approximately the same extent.

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