Geno Pharmaceuticals
 
 
Products under ENT
Cetriliv
Betahist / Betahist Forte
Fluner
Cipti/Cipti Forte
Desol
Evica
Snizof
Terbutin
Tricobal - OD
Vertigon Forte
Brupal/Brupal Forte
Fusigen Spray
Cetriliv AC
Vertigon

Snizof

COMPOSITION

Paracetamol    325 mg
Chlorpheniramine Maleate 2 mg
Phenylephrine HCL  5 mg
Caffeine 30 mg

ANTIHISTAMINES, DECONGESTANTS, MOOD ELEVATOR AND ANALGESICS (SYSTEMIC} DESCRIPTION

Antihistamine, decongestant, and analgesic combination are taken by mouth to relieve the sneezing, runny nose, nasal congestion ( stuffy nose), fever, headache and aches.

Chlorphenirarmne Maleate - Antihistamine blocks HI receptor thus controls allergic manifestation
phenylephrine HCL - Nasal decongestant. It is selective alpha adreno receptor agonist, Thus constricts the blood vessel which leads to clearing of nasal passage.

PARAMETER

PPA

PSUEDOEPHEDRINE

PHENYLEPHRINE

Adrenergic Alpha-1 Receptor Selectivity

Nonselective

Nonselective

Selective

Bleed Pressure

Increase

Increase

Less chance

CNS Side Effects 1 Nervousness, Anxiety, Loss of Appetite Insomnia)

       Yes

Yes

Less

Urinary bladder obstruction

Yes

Yes

No

Rebound hyperemia

High

High

No

US FDA

Banned

Warned

Approved

Drug Addiction

Low

High

No

Reported
adverse effect

Intracerebral hemorrhage

Drug addiction

No

US FDA WARNING AGAINST PPA
The Food and Drug Administration (FDA) is taking steps to remove phenylpropanolamine (PPA) from all drugs and has requested that all drug companies discontinue marketing products containing PPA

REASON
phenylpropanolamine and risk of Hemorrhagic Stroke: Final Report of the Hemorrhagic Stroke Project. It can also aggravate diabetes, glaucoma and Prostate enlargement

SIDE EFFECTS OF PSEUDOEPHEDRINE

  • Stimulation of the nervous system leading to nervousness, restlessness and excitability.
  • Dizziness, headache, fear, anxiety, tremor.
  • Hallucinations and convulsion (Seizure)

CAFFEINE - EFFECTS OF CAFFEINE ON THE NERVOUS SYSTEM
Caffeine is a central nervous system stimulant and belongs to the methylxanthine derivative. In moderate doses, caffeine can increase alertness.Caffeine enters the bloodstream through the stomach and small intestine and can have its effects within 15 minutes after it is
consumed,

Read More
©2017 Reserved by Geno Pharmaceuticals Pvt. Ltd.
Developed by APJ Systems
Best view at 1024 x 768 resolution